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Selected Publication:
Boersch, A; Callingham, BA; Lembeck, F; Sharman, DF.
Enzymic oxidation of capsaicin.
BIOCHEM PHARMACOL. 1991; 41(12): 1863-1869.
Doi: 10.1016/0006-2952(91)90125-O
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- Co-authors Med Uni Graz
- Lembeck Fred
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- Abstract:
- The oxidation of capsaicin (8-methyl-N-vanillyl-6-nonenamide) has been investigated by means of electrochemical, enzymic and chemical procedures. Capsaicin appears to form a fluorescent dimer comparable with those known to be formed from some other compounds bearing the vanillyl(4-hydroxy-3-methoxybenzyl-) group. If such a dimer of capsaicin were to be formed in tissues, it would bind tightly to lipid structures and its formation would prove difficult to follow. Tests on other substances bearing the vanillyl group that might be used to investigate the dimerization reaction in tissues and tissue extracts showed that 4-hydroxy-3-methoxyphenylacetic acid is a poor second substrate for peroxidase reactions. It was found that 2-methoxy-4-methylphenol (creosol) was more suitable. These results support the suggestion that the oxidation of capsaicin may be involved in some of its biological actions.
- Find related publications in this database (using NLM MeSH Indexing)
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