Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sadoghi, P; Leithner, A; Clar, H; Glehr, M; Wibmer, C; Bodo, K; Quehenberger, F; Windhager, R.
The threat of misdiagnosis of primary osteosarcoma over the age of 60: a series of seven cases and review of the literature.
Arch Orthop Trauma Surg. 2010; 130(10): 1251-1256.
Doi: 10.1007/s00402-009-1011-9
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Sadoghi Patrick
- Co-Autor*innen der Med Uni Graz
- Bodo Koppány Bonifác
- Clar Heimo
- Glehr Mathias
- Quehenberger Franz
- Wibmer Christine Linda
- Windhager Reinhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background Osteosarcoma is the most common, non-haematopoietic, primary malignant bone tumour with an incidence of 0.3-0.5 per 100,000. There is some discrepancy in literature concerning the peaks of incidence of osteosarcoma. Some describe only one peak which arises in adolescence, whilst others report a bimodal age distribution with a second peak over the age of 60. In this retrospective study, we evaluated osteosarcoma patients over age 60 treated at our department and reviewed previous studies from the literature. Patients and methods Sixty-four patients (40 male, 24 female) with a mean age of 29 years (from 7 to 82) were treated for primary osteosarcomas. At the time of diagnosis, seven patients (two male and five female) were over 60 years of age with a mean follow-up of 46 months after definite diagnosis. Results Three out of seven osteosarcomas were primarily radiologically or histologically misdiagnosed, but only one was mistreated with intramedullary nailing at a trauma centre. At last follow-up, two patients had died from the disease, three were alive with disease, and two had no evidence of osteosarcoma. Conclusions We did not find an increased incidence of primary osteosarcoma in the elderly; yet, older patients had a higher rate of misdiagnosis due to untypical radiological findings in combination with longer times from the onset of first symptoms to definite diagnosis. In cases of pathological fracture, it is essential to assess whether it is caused by mechanical stress or a primary or secondary tumour before leading into mistreatment, especially in older patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- Bone Neoplasms - diagnosis
- Child -
- Diagnostic Errors -
- Female -
- Humans -
- Male -
- Middle Aged -
- Osteosarcoma - diagnosis
- Retrospective Studies -
- Young Adult -
- Find related publications in this database (Keywords)
- Osteosarcoma
- Elderly
- Diagnosis
- Treatment
- Latency period