Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rabensteiner, DF; Trummer, G; Spitzenberger, H; Faschinger, C; Schmut, O; Wedrich, A.
Positive Influence of Hyaluronate on Cell Vitality of Human Conjunctival Cells after Alkali Injuries.
Ophthalmologica. 2010; 224(4): 217-223.
Doi: 10.1159/000260227
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Rabensteiner Dieter Franz
- Co-Autor*innen der Med Uni Graz
- Faschinger Christoph
- Schmut Otto
- Trummer Gabriele
- Wedrich Andreas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background: To analyse the influence of hyaluronate (HA) on the cell vitality of human conjunctival cells after chemical injuries from NaOH or alkali-containing household cleaners. Methods: Human conjunctival cells (Chang cells) were incubated either with NaOH solutions or dilutions of household cleaners. HA (0.025%) was added to the cell culture medium of part of the cells subsequent to chemical injuring. After 24 h the cell vitality of the HA-incubated cells, determined by MTS assay (Cell Titer 96(R) Aqueous One Solution Cell Proliferation Assay), was compared to the control cells without HA addition. Results: The addition of HA to the cell culture medium subsequent to chemical injuring resulted in a significantly lower decrease in cell vitality (mean difference: 11.79; p = 0.00; CI = 98%). Conclusion: Because HA attenuates the decrease in cell vitality of alkali-damaged human conjunctival cells, formulations containing HA may be recommended for the treatment of chemical injuries to the anterior part of the eye. Copyright (C) 2009 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic - pharmacology
- Alkalies - toxicity
- Cell Count - methods
- Cells, Cultured -
- Conjunctiva - cytology
- Dose-Response Relationship, Drug -
- Drug Interactions -
- Humans -
- Hyaluronic Acid - pharmacology
- Statistics, Nonparametric -
- Find related publications in this database (Keywords)
- Alkali injuries
- Conjunctiva
- Hyaluronate