Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mangge, H; Pietsch, B; Lindner, W; Warnkross, H; Leb, G; Schauenstein, K.
Enhancing in vivo effect of propranolol on human lymphocyte function is not due to stereospecific beta-adrenergic blockade.
Agents Actions. 1993; 38(3-4):281-285
Doi: 10.1007/BF01976221
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Schauenstein Konrad
- Co-Autor*innen der Med Uni Graz
- Leb Georg
- Obermayer-Pietsch Barbara
- Warnkroß Helga
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- Abstract:
- Immunoenhancing in vivo effects of beta-adrenergic blockers have been previously ascribed to a reduced beta-receptor-mediated immunosuppression. In the present study using a whole blood stimulation assay, the effects of a five-day treatment with the purified (R)- or (S)-isomer of propranolol (3 x 40 mg/day) on the polyclonal in vitro responsiveness of peripheral blood lymphocytes (PBL) of normothyroid and hyperthyroid persons were assessed. It is shown that both isomers likewise exhibit a significant enhancing effect on the proliferative response of PBL to T and B cell mitogens, which strongly argues for nonspecific effects of propranolol to be responsible rather than a specific beta-adrenergic receptor blockade.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Follow-Up Studies -
- Humans -
- Hyperthyroidism - immunology
- Leukocyte Count - drug effects
- Lymphocyte Activation - drug effects
- Middle Aged -
- Propranolol - administration & dosage Propranolol - pharmacology
- Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism
- Stereoisomerism -
- T-Lymphocytes - drug effects T-Lymphocytes - immunology