Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Auerswald, G; Muntean, W; Kemkes-Matthes, B; Klamroth, R; Krause, M; Kurnik, K; Oldenburg, J; Pabinger-Fasching, I; Schramm, W; Zimmermann, R; Zotz, RB.
Relevance of a single dose of 270 microg/kg recombinant factor VIIa for the treatment of patients with haemophilia and inhibitors - Recommendations from the GTH experts
Hamostaseologie. 2009; 29(2): 197-203.
Doi: 10.1055/s-0037-1617025
PubMed
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- Co-Autor*innen der Med Uni Graz
- Muntean Eugen
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- Abstract:
- Recombinant factor VIIa (rFVIIa; NovoSeven) is, besides other indications, authorised for the treatment of bleeding episodes in patients with hereditary haemophilia A or B and inhibitors. Based on the results of three clinical studies, marketing authorisation was granted for the single dose of 270 microg/kg body weight rFVIIa for the treatment of mild to moderate bleeding episodes in patients with haemophilia A or B with inhibitors in March 2007. Thereupon, an expert group analysed the relevance of this additional treatment option for clinical routine. Compared with the repeated application of 90 microg/kg body weight rFVIIa, quality of life may be improved if the single dose of 270 microg/kg body weight rFVIIa reduces the number of injections. The single dose has a benefit for those patients who require several rFVIIa applications or who do not respond adequately to low doses. Moreover, patients with poor venous access or patients who fear injections or reject them (especially children) may benefit from the single dose. The prescription of 270 microg/kg body weight rFVIIa as a single dose instead of multiple dosing of 90 microg/kg body weight is basically an individual and indication-related decision.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Dose-Response Relationship, Drug -
- Factor VIIa - adverse effects Factor VIIa - genetics Factor VIIa - therapeutic use
- Female -
- Hemophilia A - drug therapy
- Hemophilia B - drug therapy
- Humans -
- Male -
- Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use
- Thromboembolism - chemically induced Thromboembolism - prevention and control