Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fioredda, F; Moser, A; Bertoluzzo, L; Lackner, H; Giacchino, R; Laspina, M; Lazier, L; Riva, C; Giacchino, M; Fraschini, D; Frey, E; Sementa, A; Pistorio, A; Haupt, R; On behalf of I-BFM ELTEC (Early and Late Toxicity Educational Committee).
Natural course of HCV infection in childhood cancer survivors.
Support Care Cancer. 2010; 18(11):1413-1420
Doi: 10.1007/s00520-009-0763-7
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Nebl Andrea Maria
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- Abstract:
- Goals of work To describe the course of hepatitis C in a cohort of 105 survivors after childhood cancer. Patients and methods Data on chemo/radiotherapy, clinical status, serial alanine aminotransferase (ALT) evaluation, and virological parameters after the end of treatment were collected for each patient. Liver biopsies, when performed, were centrally evaluated by a pathologist. Main results All patients were alive at the end of follow-up and did not show hepatic insufficiency. ALT evaluation along the entire follow-up showed a moderate (87%) or a remarkable (13%) cytolytic pattern. Young age at diagnosis, hematopoietic stem cell transplantation, and duration of infection significantly correlate with a worse hepatic activity. Type of tumor and chemo and/or radiotherapy regimens did not influence the pattern of hepatic cytolysis. Liver biopsy, centrally reviewed in 30% of the cohort, showed one case of cirrhosis and mild fibrosis in 71% of the group. Higher degrees of fibrosis did not seem to be related to any exposition to chemo/radiotherapy but correlated significantly with the more remarkable cytolytic course. Conclusions The outcome of hepatitis C in our patients is comparable to the one described in European cohorts of adult cancer survivors and perinatally infected subjects. Nevertheless, progression to high degrees of hepatic damage has to be monitored by a careful follow-up.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Biopsy -
- Child -
- Disease Progression -
- Disease Progression - epidemiology
- Female -
- Follow-Up Studies -
- Hepatitis C, Chronic - epidemiology
- Humans -
- Liver Function Tests -
- Male -
- Neoplasms - complications
- Retrospective Studies -
- Risk Factors -
- Survivors -
- Time Factors -
- Young Adult -
- Find related publications in this database (Keywords)
- Chronic hepatitis C
- Long-term survivors
- HCV after cancer