Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fink, AM; Kaltenegger, I; Schneider, B; Frühauf, J; Jurecka, W; Steiner, A.
Serum level of VEGF-D in patients with primary lymphedema.
Lymphology. 2004; 37(4): 185-189.
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Frühauf Julia
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- Abstract:
- Recent studies have indicated that vascular endothelial growth factor-D (VEGF-D) stimulates lymphangiogenesis in humans. Furthermore, mutations of vascular endothelial growth factor receptor 3 (VEGFR-3) have been observed in families with hereditary lymphedema. The lack of stimulation of lymphangiogenesis could lead to production of even more VEGF-D to obtain stimulation of lymphangiogenesis resulting in a high serum level of VEGF-D. The aim of the present study was to compare the serum level of VEGF-D in patients with primary lymphedema with healthy controls. In a prospective study, the serum level of VEGF-D was determined by a solid phase ELISA in patients with primary lymphedema and compared with healthy controls. In the group of patients with primary lymphedema the serum level of VEGF-D was significantly higher compared with controls (p=0.0047). The increased levels of VEGF-D observed in the present study suggest that primary lymphedema may be based on defective stimulation of VEGFR-3.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Female -
- Humans -
- Lymphedema - blood Lymphedema - genetics Lymphedema - metabolism
- Male -
- Middle Aged -
- Prospective Studies -
- Vascular Endothelial Growth Factor D - blood
- Vascular Endothelial Growth Factor Receptor-3 - genetics Vascular Endothelial Growth Factor Receptor-3 - metabolism