Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Amrein, K; Katschnig, C; Sipurzynski, S; Stojakovic, T; Lanzer, G; Stach, E; Pieber, TR; Dobnig, H.
Apheresis affects bone and mineral metabolism.
Bone. 2010; 46(3): 789-795.
Doi: 10.1016/j.bone.2009.11.008
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Amrein Karin
- Co-Autor*innen der Med Uni Graz
- Dobnig Harald
- Lanzer Gerhard
- Pieber Thomas
- Sipurzynski Sabine
- Stojakovic Tatjana
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- Abstract:
- Background: Apheresis is a procedure to selectively obtain blood components. For the collection process citrate is routinely used. It inhibits coagulation by binding to ionized calcium and leads to metabolic alkalosis. Objective: Whether regular apheresis affects bone and mineral metabolism is unknown. The intention of this study was to investigate 1) the acute effects of apheresis on acid-base balance, bone and mineral metabolism and 2) to compare bone mineral density (BMD) at the lumbar spine and hip of donors to matched control subjects. Design: In this open, observational, single-center, cross-sectional study we enrolled 102 regular plasma and thrombocyte donors to purse objective 1) and compared those to 102 matched controls (CTR) for objective 2). Results: Platelet donation led to significant decreases in serum ionized calcium (- 17%) and phosphate (- 18%). to marked increases in base excess (57%) and PTH levels (192%) during apheresis. Baseline biochemical comparisons between donors and CTR revealed significantly lower values for donors for serum calcium, albumin, and 25-hydroxyvitamin D levels. Mean Z-score at the lumbar spine adjusted for BMI, average physical activity and daily calcium intake was lower for donors (-0.28 +/- 0.11) when compared to CTR subjects (0.06 +/- 0.11, P<0.05). Total and neck femoral BMD was also lower in the donor group, however, this difference was not significant. Conclusions: Exposure to citrate during the apheresis procedure acutely affects mineral and bone metabolism. Regular donations of blood components compromised BMD at the lumbar spine. If confirmed, strategies to prevent long-term effects on bone need to be formulated. (C) 2009 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acid-Base Equilibrium - physiology
- Adult -
- Biological Markers - metabolism
- Blood Donors -
- Bone Density - physiology
- Cross-Sectional Studies -
- Electrolytes - blood
- Female -
- Femur Neck - metabolism
- Humans -
- Lumbar Vertebrae - metabolism
- Male -
- Middle Aged -
- Plasmapheresis - adverse effects
- Plateletpheresis - adverse effects
- Find related publications in this database (Keywords)
- Acid-base balance
- Calcium
- Vitamin D
- Osteoporosis
- Blood donation
- Metabolic alkalosis
- Bone mineral density