Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Steinbrugger, I; Haas, A; Renner, W; Mayer, M; Wedrich, A; El-Shabrawi, Y; Werner, C; Schmut, O; Weger, M.
Die Bedeutung des C3 Arg102Gly Genpolymorphismus als Risikofaktor für die exsudative altersabhängige Makuladegeneration.
Spektrum der Augenheilkunde. 2009; 23(5): 353-357.
Doi: 10.1007/s00717-009-0355-4
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- Führende Autor*innen der Med Uni Graz
- Steinbrugger Iris
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Haas Anton
- Mayer Monika
- Renner Wilfried
- Schmut Otto
- Wedrich Andreas
- Werner Christoph
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- Abstract:
- BACKGROUND: Several gene polymorphisms, including complement factor H (CFH) Tyr402His, complement factor B (CFB) Leu9His and complement component 2 (C2) IVS10C > T, have previously been associated with altered risk for exudative age-related macular degeneration (AMD). A complement component 3 (C3) Arg102Gly gene polymorphism has been identified as a novel risk factor for exudative AMD in both a British and North American population. The present study was set to investigate a hypothesized association between the C3 102Gly allele with exudative AMD in an Austrian population. METHODS: Genotypes of the C3 Arg102Gly, CFB Leu9His, C2 IVS10C > T and CFH Tyr402His polymorphisms were determined in 269 patients with exudative AMD and 155 control subjects. RESULTS: Presence of the C3 102Gly allele was significantly associated with exudative AMD (p = 0.001). Univariate analysis revealed an odds ratio of 1.71 (95% confidence interval (CI): 1.13-2.60) for exudative AMD among heterozygotes for the C3 102Gly allele compared to those carrying the wildtype, while an OR of 3.76 (95% CI: 1.25-11.34) was observed among subjects carrying the homozygous C3 102Gly/Gly genotype. In a stepwise logistic regression model including CFH Tyr402His, CFB Leu9His and C2 IVS10C > T genoytpes, odds ratios of 1.88 (95% CI: 1.18-2.99) for heterozygous and 3.46 (95% CI: 1.07-11.16) for homozygous carriers of the C3 102Gly allele were observed. CONCLUSIONS: Our data provide further evidence that in addition to other complement gene polymorphisms the C3 102Gly variant is associated with exudative AMD in an Austrian population.
- Find related publications in this database (Keywords)
- Gene polymorphism
- risk factor
- age-related macular degeneration