Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmut, O; Kain, R; Peterz, I; Rabensteiner, DF; Wachswender, C; Wedrich, A.
Die Therapie des Keratokonus mit Riboflavin und UV-A-Licht - biochemische Aspekte
Spektrum der Augenheilkunde. 2009; 23: 337-342.
Doi: 10.1007/s00717-009-0352-7
Web of Science
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schmut Otto
- Co-Autor*innen der Med Uni Graz
- Rabensteiner Dieter Franz
- Wachswender Christine
- Wedrich Andreas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A new additional therapy of keratoconus is photooxidative crosslinking of corneal collagen with riboflavin and UV-A-light. The method is currently undergoing clinical evaluation worldwide especially concerning late complications. In this study we confirm collagen crosslinking by formation of stable gels from corneal collagen solutions during irradiation with riboflavin addition. However the hyaluronate molecule, a representative glycosaminoglycan of the cornea, is degraded to small fragments by UV-A irradiation with addition of riboflavin as shown by viscometry. Analysis by polyacrylamidegel electrophoresis shows that also tear fluid proteins are destroyed by this method. This may explain the occasionally occurring haze of cornea and glare sensitivity of patients after photo-oxidative crosslinking therapy of keratoconus.
- Find related publications in this database (Keywords)
- Keratoconus
- riboflavin
- UV-light
- collagen
- hyaluronate
- crosslinking