Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schildhauer, TA; Seybold, D; Gessmann, J; Muhr, G; Koller, M.
Fixation of porous calcium phosphate with expanded bone marrow cells using an autologous plasma clot
MATERIALWISS WERKSTOFFTECH. MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK; 38: 1012-1014.
Doi: 10.1002/mawe.200700239
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Schildhauer Thomas Armin
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- Abstract:
- Multipotent human mesenchymal stromal cells (hMSCs) are currently the most promising cell type for regenerative medicine and tissue engineering. For clinical applications with special focus on fracture repair a method to deliver in vitro-expanded bone marrow cells to the fracture site is presented. Autologous blood plasma clotting was used to fix expanded cells and synthetic tricalcium phosphate particles. A, jelly-like but solid composite matrix was obtained which could easily be handled by the surgeon. The majority of embedded cells remained viable after the plasma gelation process, as was determined by fluorescence microscopy. Experimental cell culture over a period of 15 days showed proliferating mesenchymal stromal cells within the plasma clot.
- Find related publications in this database (Keywords)
- porous calcium phosphate
- plasma clot
- stromal cells