Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cygan, B; Czabak-Garbacz, R; Chomicki, M; Teter, M; Kozlovsky, I.
Comparison of the influence of diazepam and new benzodiazepine derivative (BD-1158) on the behaviour of rabbits under spontaneous conditions
BULL VET INST PULAWY. 2004; 48(4): 499-501.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- The purpose of the present study was to compare the activity and side effects of diazepam and new benzodiazepine derivative (BD-1158). The experiments were performed in 2 groups of rabbits. In the first group BD-1158 was administered intraperitoneally at a dose of 10 mg/kg of body weight, diluted in 1% starch solution up to 1 ml. In the second group diazepam was injected intravenously at a dose of 1 mg/kg. The substances were administered 35-40 min before the behaviour recording. It was found that both substances produced similar effects on animal behaviour under physiological conditions. They had a strong anxiolytic and sedative influence and decreased orientation-searching reactions, grooming, and water and feed uptake.
- Find related publications in this database (Keywords)
- rabbits
- diazepam
- benzodiazepines
- behaviour