Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czabak-Garbacz, R; Chomicki, M; Cygan, B; Khonicheva, NM.
Influence of diazepam on the escape reaction and rabbits' behaviour under stress
BULL VET INST PULAWY. 2004; 48(4): 493-497.
Web of Science
- Führende Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- The purpose of the study was to assess the influence of diazepam (DZ, administered iv. at the doses of 0.2 and 1.0 mg/kg) on the escape reaction and rabbit's behaviour under stress evoked by repetitive electric stimulation of the ventromedial nucleus of the hypothalamus (VMH). Both DZ doses had no significant influence on the latent time of the escape reaction, but they changed the structure of rabbits' behaviour, decreasing the tension and exploration phases and prolonging comfort. Changes were more potent during the first than the second hour of the experiment. The dose of 1.0 mg/kg had generally similar but a stronger effect on the behaviour than the dose of 0.2 mg/kg. DZ acted as an efficient anxiolytic and sedative drug, which eliminated symptoms of stress. Its effects in the reduction of rabbit's fear and anxiety depended on the dose and time after its administration.
- Find related publications in this database (Keywords)
- rabbits
- diazepam
- escape
- reaction
- behaviour stress
- hypothalamus