Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cygan, B; Czabak-Garbacz, R; Chomicki, M; Teter, M; Kozlovsky, G.
Comparison of the influence of diazepam and new benzodiazepine derivative (BD-1158) on the rabbits' behaviour after electrical stimulation of the ventromedial hypothalamic nucleus
BULL VET INST PULAWY. 2005; 49(3): 357-360.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- The aim of the present study was to compare the influence of diazepam and new benzodiazepine derivative BD-1158 on different forms of rabbits' behaviour after ventromedial hypothalamic nucleus (Vmh) stimulation. The experiments were performed in 2 groups of animals. In the first group, diazepam was injected intravenously at a dose of I mg/kg. In the second group, BD-1158 was administered intraperitoneally at a dose of 10 mg/kg, diluted in 1% starch solution up to 1 ml. The substances were administered 35-40 min before the behaviour recording. Each daily session lasted 2 h. It was divided into 10-minute intervals. Electrical stimulation of the Vmh was induced at the beginning of each 10 min interval for the whole time of the experiment until the escape reaction occurred. It was found that both agents exert anxiolytic and sedative effects, they do not prove to be factors in modulating grooming, eating and drinking in experimental stress situation. Diazepam influence on orientation-searching reactions is more stronger than BD-1158 influence.
- Find related publications in this database (Keywords)
- rabbits
- benzodiazepines
- ventromedial hypothalamic nucleus
- stress
- behaviour