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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Frudinger, A; Kölle, D; Schwaiger, W; Pfeifer, J; Paede, J; Halligan, S.
Muscle-derived cell injection to treat anal incontinence due to obstetric trauma: pilot study with 1 year follow-up.
Gut. 2010; 59(1):55-61
Doi: 10.1136/gut.2009.181347
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Frudinger Andrea
- Co-authors Med Uni Graz
- Pfeifer Johann
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- Abstract:
- OBJECTIVE: To treat anal incontinence due to obstetric external anal sphincter disruption via injection of autologous myoblast cells. DESIGN: Observational pilot study. SETTING: University hospital and district hospital PATIENTS: 10 women suffering from anal incontinence due to obstetric anal sphincter injury, refractory to conventional non-surgical therapy. INTERVENTIONS: Autologous myoblasts were cultured from a pectoralis muscle biopsy, harvested, and injected into the external anal sphincter defect using direct ultrasound guidance. MAIN OUTCOME MEASURES: Wexner incontinence score, anal squeeze pressures, and quality of life 12 months after injection. Safety and technical feasibility. RESULTS: The procedure was well tolerated and no adverse events were observed. At 12 months the Wexner incontince score had decreased by a mean of 13.7 units (95% CI, -16.3 to -11.2), anal squeeze pressures were unchanged, and overall quality of life scores improved by a median of 30 points (95% CI, 25 to 42). Anal squeeze pressures did rise significantly at 1 month and 6 months post-injection (p = 0.03). CONCLUSIONS: Injection of autologous myoblasts is safe, well tolerated, and significantly improves symptoms of anal incontinence due to obstetric anal sphincter trauma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Anal Canal - diagnostic imaging, injuries, physiopathology
- Cell Culture Techniques - administration & dosage
- Endosonography - administration & dosage
- Epidemiologic Methods - administration & dosage
- Fecal Incontinence - diagnostic imaging, etiology, physiopathology, therapy
- Female - administration & dosage
- Humans - administration & dosage
- Myoblasts, Skeletal - transplantation
- Obstetric Labor Complications - administration & dosage
- Pregnancy - administration & dosage
- Pressure - administration & dosage
- Psychometrics - administration & dosage
- Quality of Life - administration & dosage
- Treatment Outcome - administration & dosage
- Ultrasonography, Interventional - administration & dosage