Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Khonicheva, NM; Loseva, EV; Czabak-Garbacz, R; Loriia, MV; Airapetiants, MG.
A special case of learning disruption as a model of a disintegration phenomenon
Zh Vyssh Nerv Deiat Im I P Pavlova. 2005; 55(3):393-399
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- Combination of two factors in rats such as the isolation (during 2-4 months, beginning from the 21st day of age) and procedure of space cyclic learning results in a rare kind of behavioral strategy (in 30% animals), when the cyclic behavior is realized without food reinforcement. Such a dissociation between the vital motivation and searching behavior may be considered as an analogue of the disintegration phenomenon in neuropsychotic patients. The deep depression of learning owing to lowering of search represents the dominant type of behavioral disorders in isolants. The cyclic habit training, including a 2-months pause between two sessions, significantly increases behavioral search activity. The behaviors are accompanied by morphological shifts in the sensomotor cortex: significant decrease of the fifth layer (giant pyramids) thickness, selective lowering in the satellite glia density and elimination of normal behavior-glia correlations.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Appetitive Behavior - physiology
- Avoidance Learning - physiology
- Cerebellar Cortex - pathology
- Male -
- Maze Learning - physiology
- Neurotic Disorders - physiopathologyNeurotic Disorders - psychology
- Rats -
- Rats, Wistar -
- Social Isolation -
- Find related publications in this database (Keywords)
- behavior
- space learning
- cognition
- social deprivation
- isolation
- psychoneurotic disorders
- brain cortex
- neuroglia