Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cygan, B; Wójcik, G; Czabak-Garbacz, R; Teter, M; Kozlovsky, I.
The influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits in spontaneous conditions.
Ann Univ Mariae Curie Sklodowska Med. 2001; 56(2): 275-279.
PubMed
- Co-Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- BD-1158 is a new 1,4 benzodiazepine derivative. The purpose of the present experiments was to test the spontaneous behaviour (typical of a rabbit) after administration of BD-1158 and thus to define the activity and side effects of this substance under physiological conditions. The experiments were performed for 3 subsequent days in a group of 10 rabbits. On the first day spontaneous behaviour was tested. On the second day 1 ml of 1% starch solution was administered intraperitoneally. On the third day BD-1158 was administered intraperitoneally at a dose 10 mg/kg diluted in 1% starch solution up to 1 ml, 35-40 minutes before the beginning of the experiment. Six phases of behaviour were estimated. It was concluded that BD-1158 has a strong anxiolytic and sedative effect, decreases the state of animal's attention, water and food uptake.
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