Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czabak-Garbacz, R; Cygan, B; Wolanski, L; Kozlovsky, I.
Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight.
Pharmacol Rep. 2006; 58(4):562-567
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- Führende Autor*innen der Med Uni Graz
- Czabak-Garbacz Roza
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- Abstract:
- TP-7 is a synthetic analogue of tuftsin. It has a structure of tuftsin, to which three natural L-amino-acids Pro-Gly-Pro are attached. This heptapeptide improves learning and memorization and causes antidepressant and anxiolytic effect. It is possible to use TP-7 in the future to optimize cognitive functions and as a potential new anxioselective, fast-acting and easy-dosed drug. Therefore, it was purposeful to study such properties of the heptapeptide as its influence on anxiety-fear and body weight under a long-term treatment regimen. The experiment was performed on 24 preselected Wistar rats with the use of Rodina's method. There were three experimental groups of animals with high initial emotional reactivity: passive control group (P), active control group (A, receiving distilled water) and group treated with TP-7 at the dose of 0.3 mg/kg (T). The rats of A and T groups received intraperitoneal injections every day. The experiments were conducted 15 min after the administration of the drug, one and two days after initial testing day, then 1, 2, 3 and 4 weeks after that. The heptapeptide reduced the anxiety-phobic states significantly starting from the second day of drug application. The observed effects persisted throughout four weeks of the experiment, which confirmed effective long-term anxiolytic properties of the heptapeptide. TP-7 did not cause any changes in the body mass by itself.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Anxiety Agents - pharmacologyAnti-Anxiety Agents - therapeutic use
- Anxiety - drug therapy
- Behavior, Animal - drug effects
- Body Weight - drug effects
- Fear - drug effects
- Male -
- Motor Activity - drug effects
- Oligopeptides - pharmacologyOligopeptides - therapeutic use
- Phobic Disorders - drug therapy
- Rats -
- Rats, Wistar -
- Reaction Time - drug effects
- Time Factors -
- Tuftsin - analogs and derivativesTuftsin - pharmacologyTuftsin - therapeutic use
- Find related publications in this database (Keywords)
- tuftsin analogue
- anxiety
- body weight
- rat