Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Liegl-Atzwanger, B; Hofmann, G; Leithner, A; Beham, A.
Undifferentiated high-grade pleomorphic sarcoma (UHPS): Diagnostic criteria, differential diagnosis, and treatment. An attempt to erasure the misnomer MFH
EUR SURG. 2009; 41(4): 143-149.
Doi: 10.1007/s10353-009-0474-9
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Liegl-Atzwanger Bernadette
- Co-Autor*innen der Med Uni Graz
- Beham Alfred
- Hofmann Guenter
- Leithner Andreas
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- Abstract:
- BACKGROUND: For many years malignant fibrous histiocytoma ("MFH") was accepted to be the most common soft tissue sarcoma in adults, its histiogenesis, however, remained controversial. METHODS: Review of the current status of "MFH". RESULTS: Within the last two decades several studies demonstrated that "MFH" has been used as a "waste paper basket" for several better classifiable, poorly differentiated soft tissue sarcomas. Therefore, reclassification of these tumors could led to better prognostification. CONCLUSIONS: In the 21st century with the insight of immunohistochemistry as well as improved cytogenetic and molecular diagnostic the term high-grade undifferentiated pleomorphic sarcoma (so-called "MFH") should be restricted to a group of soft tissue malignancies without a specific line of differentiation. Better classification of various high-grade sarcomas may contribute to more specific treatment options and hence lead to improved survival for patients.
- Find related publications in this database (Keywords)
- Sarcoma
- high-grade pleomorphic sarcoma
- undifferentiated sarcoma
- MFH