Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ortuno, F; Arbizu, J; Soutullo, CA; Bonelli, RM.
Is there a cortical blood flow redistribution pattern related with perseverative error in schizophrenia?
PSYCHIATR DANUB. 2009; 21(3): 283-289.
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Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Bonelli Raphael
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- Abstract:
- Background. We studied relative cortical blood flow (relCBF) patterns associated to correct performance (CP) and perseverative error (PE) during Wisconsin Card Sorting Test (WCST) execution, in controls and patients with schizophrenia. Subjects and methods: relCBF (regional cortical blood flow (rCBF) / whole cortex blood flow) of 10 well defined cortical regions was measured in 18 patients with schizophrenia and 13 healthy controls by a Technetium - 99 - HMPAO SPECT, at rest and while they performed WCST. Results: Patients made significantly more PE than controls during WCST performance. In patients, we found a significant correlation between PE and relCBF in right occipital cortex. In controls, we found a significant correlation between CP and relCBF of several cortical regions during WCST execution: left orbitofrontal cortex and left global frontal cortex positively and parietal bilateral cortex negatively. PE was inversely correlated with relCBF in left temporal cortex. Conclusions: Successful WCST performance is associated to a high left frontal activity in controls but not inpatients. The severity of PE during WCST performance is associated to a low left frontal-temporal activity in controls and to a high right parietal-occipital activity in schizophrenia. This may represent a cortical activity redistribution pattern related to perseveration in schizophrenia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Attention - physiology
- Brain Mapping -
- Cerebral Cortex - blood supply
- Cognition Disorders - physiopathology
- Dominance, Cerebral - physiology
- Female -
- Humans -
- Male -
- Memory, Short-Term - physiology
- Middle Aged -
- Neuropsychological Tests -
- Regional Blood Flow - physiology
- Schizophrenia - physiopathology
- Schizophrenic Psychology -
- Stereotyped Behavior - physiology
- Technetium Tc 99m Exametazime - diagnostic use
- Tomography, Emission-Computed, Single-Photon -
- Young Adult -
- Find related publications in this database (Keywords)
- schizophrenia
- Wisconsin Card Sorting Test
- SPECT
- perseveration
- prefrontal cortex