Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Castellani, C; Bimbashi, P; Ruttenstock, E; Sacherer, P; Stojakovic, T; Weinberg, AM.
Neuroprotein s-100B -- a useful parameter in paediatric patients with mild traumatic brain injury?
Acta Paediatr. 2009; 98(10): 1607-1612.
Doi: 10.1111/j.1651-2227.2009.01423.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Castellani Christoph
- Weinberg Annelie-Martina
- Co-Autor*innen der Med Uni Graz
- Ruttenstock Elke Maria
- Stojakovic Tatjana
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- Abstract:
- Aims: To examine the correlation of S-100B to cranial computerized tomography (CCT) scan results in children after mild traumatic brain injury (MTBI). Methods: One hundred and nine paediatric patients (0-18 years) with MTBI were included in this prospective single-centre study. Serum was collected within 6 h of trauma for determination of serum S-100B. The upper reference of S-100B was set to 0.16 mu g/L. A CCT scan was performed in all patients and the results were correlated to the S-100B values. Results: Computerized tomography was abnormal in 36 patients showing intracerebral haemorrhages and/or skull fractures. Serum S-100B level was significantly higher in patients with a pathological condition as shown in CT scan results (p = 0.003). There were no false negative, but 42 false positive test results for S-100B. This resulted in a sensitivity of 1.00, specificity of 0.42, positive predictive value of 0.46 and negative predictive value of 1.00. An area under the receiver operating curve of 0.68 was calculated. Conclusion: S-100B is a valuable tool to rule out patients with pathological CCT findings in a collective of paediatric patients with MTBI. Elevations of S-100B do not necessarily lead to a pathological finding in the CT scan, but values below the cut-off safely rule out the evidence of intracranial lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Area Under Curve -
- Biological Markers - blood
- Brain Injuries - blood Brain Injuries - diagnosis
- Child -
- Child, Preschool -
- False Positive Reactions -
- Female -
- Humans -
- Infant -
- Male -
- Prospective Studies -
- Reference Values -
- S100 Proteins - blood
- Sensitivity and Specificity -
- Statistics, Nonparametric -
- Tomography, X-Ray Computed - methods
- Find related publications in this database (Keywords)
- Children
- Mild traumatic brain injury
- Neuroprotein
- Neurotrauma
- S-100