Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Altamura, D; Menzies, SW; Argenziano, G; Zalaudek, I; Soyer, HP; Sera, F; Avramidis, M; Deambrosis, K; Fargnoli, MC; Peris, K.
Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis.
J Am Acad Dermatol. 2010; 62(1):67-75
Doi: 10.1016/j.jaad.2009.05.035
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zalaudek Iris
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- Abstract:
- Background: Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor. Objective: We sought to investigate the variability and diagnostic significance of dermatoscopic features of BCCs. Methods: We conducted retrospective dermatoscopic analysis of 609 BCCs and 200 melanocytic and nonmelanocytic lesions, and assessment of interrater reliability of dermatoscopic BCC criteria. Results: Lesions included nonpigmented (15.1%), lightly pigmented (33.2%), pigmented (42.7%), and heavily pigmented (9%) BCCs. Classic BCC patterns including arborizing telangiectasia (57.1%), blue/gray ovoid nests (47.5%), ulceration (39.2%), multiple blue/gray globules (26.1%), leaflike areas (15.9%), and spoke-wheel areas (9%) were significantly increased in pigmented BCCs compared with nonpigmented and heavily pigmented BCCs (P = .0001.). Among nonclassic BCC patterns, we detected short fine superficial telangiectasia (10%) and multiple small erosions (8.5%), and described two new patterns named "concentric structures" (7.6%) and "multiple in-focus blue/gray dots" (5.1%). Dermatoscopic features suggestive of melanocytic lesions (eg, multiple brown to black dots/globules, blue/white veillike structures, and nonarborizing vessels) were observed in 40.6% BCCs and significantly increased in heavily pigmented BCCs (P < .0001). Expert observers provided an accurate (sensitivity: 97%) and reliable (K: 87%) dermatoscopic diagnosis of BCC, although a significant difference in terms of specificity (P = .0002) and positive predictive value (P = .0004) was found. Arborizing telangiectasia, leaflike areas, and large blue/gray ovoid nests represented reliable and robust diagnostic parameters. Limitation: The shady was retrospective. Conclusion: BCCs show a large spectrum of global and local dermatoscopic features; heavily pigmented BCCs show the most challenging combinations of dermatoscopic features. (J Am Acad Dermatol 2010;62:67-75.)
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Basal Cell - diagnosis
- Dermoscopy -
- Female -
- Humans -
- Male -
- Middle Aged -
- Retrospective Studies -
- Sensitivity and Specificity -
- Skin Neoplasms - diagnosis
- Young Adult -
- Find related publications in this database (Keywords)
- basal cell carcinoma
- dermatoscopy
- early diagnosis of skin tumors