Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Legat, FJ; Wolf, P.
Cutaneous sensory nerves: mediators of phototherapeutic effects?
Front Biosci (Landmark Ed). 2009; 14(6):4921-4931
Doi: 10.2741/3577
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Legat Franz
- Co-Autor*innen der Med Uni Graz
- Wolf Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Exposures to ultraviolet radiation (UVR) during accidental or voluntary sun exposure or treatment with phototherapy or photochemotherapy have a significant impact on the skin. Many skin diseases such as psoriasis, atopic dermatitis, or cutaneous T-cell lymphoma significantly improve by photo(chemo)therapy, though the mechanisms behind the therapeutic effects of photo(chemo)therapy are still far from understood. Various pathways and means through which the energy of UVR from natural or artificial sources is ultimately transformed into biologic effects within the skin have been suggested and cutaneous sensory nerves, neuropeptides, neurotrophins, and certain nerve-related receptors have been among them. In fact a three-dimensional network of sensory nerve fibers derived from dorsal root ganglia intersperses all layers of the skin including the epidermis. In this forefront of defense against environmental impacts (including UVR) on the skin, sensory nerve fibers become targets by itself and closely contact resident and infiltrating cutaneous cells. Thus, terminals of cutaneous sensory nerve fibers, and neuropeptides within these fibers, are in a central position to participate in mediating therapeutic effects of photo(chemo)therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Humans -
- Models, Neurological -
- Nerve Growth Factor - physiology
- Photochemotherapy -
- Phototherapy -
- Receptors, Nerve Growth Factor - physiology
- Receptors, Neuropeptide - physiology
- Sensory Receptor Cells - cytology
- Sensory Receptor Cells - physiology
- Sensory Receptor Cells - radiation effects
- Skin - innervation
- Skin - radiation effects
- Skin Aging -
- Skin Physiological Phenomena - radiation effects
- Ultraviolet Therapy -
- Find related publications in this database (Keywords)
- Photochemotherapy
- Phototherapy
- UV radiation
- Sensory Nerve Fibers
- CGRP
- substance P
- Nerve Growth Factor
- Photoimmunology
- Neurogenic Inflammation
- Photoaging
- Photocarcinogenesis
- Review