Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dejaco, C; Duftner, C; Klauser, A; Schirmer, M.
Altered T-cell subtypes in spondyloarthritis, rheumatoid arthritis and polymyalgia rheumatica.
Rheumatol Int. 2010; 30(3): 297-303.
Doi: 10.1007/s00296-009-0949-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- The objective of the present study was to assess the prevalences of naive, memory, memory/effector, regulatory and activated T-cells in peripheral blood (PB) and synovial fluid (SF) of patients with spondyloarthritis (SpA), rheumatoid arthritis (RA), polymyalgia rheumatica/giant cell arteritis (PMR/GCA) and healthy controls (HC). Twenty-two patients with SpA, 15 patients with RA, 38 patients with PMR/GCA and 17 HC were prospectively enrolled. The expression of differentiation and activation markers (CD3, CD4, CD8, CD25, CD28, CD45RA, CD45RO) characterizing T-cell subsets were analyzed by flow cytometry. The frequency of CD3(+)CD4(+)CD28(-) memory/effector T-cells was increased in PB of patients with SpA (median 1.1%, range 0.1-69.6), RA (2.5%, 0-42.9) and PMR/GCA (2.7%, 0-49.5) when compared with HC (0.7%, 0-38.0) and tended to be higher in SF of SpA patients (4.5%, 0.2-7.2, P = 0.084). CD28(+)CD45RA(+)CD4(+) (9.6%, 4.1-10.3) and CD28(+)CD45RA(+)CD8(+) naive T-cells (15.0%, 12.9-26.2) were reduced and CD28(+)CD45RO(+)CD4(+) (93.5%, 51.0-99.0), CD28(+)CD45RO(+)CD8(+) memory (81.2%, 38.9-83.5), CD8(+)CD25(+) activated T-cells (10.9%, 2.7-13.8) and CD4(+)CD25(hi) TREGs (10.2%, 7.0-13.3) were increased in SF compared to PB (P < 0.05 each). These findings demonstrate altered T-cell subsets in patients with immune-mediated disease, particularly at sites of inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, Surface - analysis
- Arthritis, Rheumatoid - immunology
- Biological Markers - analysis
- Female -
- Flow Cytometry -
- Humans -
- Immunologic Memory - immunology
- Lymphocyte Activation - immunology
- Lymphocyte Count -
- Male -
- Middle Aged -
- Polymyalgia Rheumatica - immunology
- Predictive Value of Tests -
- Prospective Studies -
- Spondylitis, Ankylosing - immunology
- Synovial Fluid - cytology
- T-Lymphocyte Subsets - classification
- T-Lymphocytes, Regulatory - immunology
- Find related publications in this database (Keywords)
- Polymyalgia rheumatica
- Rheumatoid arthritis
- Spondyloarthritis
- Temporal arteritis
- T-lymphocytes