Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Duftner, C; Seiler, R; Dejaco, C; Fraedrich, G; Schirmer, M.
Increasing evidence for immune-mediated processes and new therapeutic approaches in abdominal aortic aneurysms--a review.
Ann N Y Acad Sci. 2006; 1085(8): 331-338.
Doi: 10.1196/annals.1383.036
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- Animal models for abdominal aortic aneurysms (AAAs), immunogenetical and pathophysiological studies support the importance of immune-mediated processes in the pathogenesis of AAA disease. Neutrophils, natural killer (NK) cells, monocytes/macrophages, and proinflammatory cytokines are involved in the complex and dynamic tissue remodeling of the AAA vessel wall. Our group showed an increased prevalence of circulating interferon-gamma (IFN-gamma) producing CD28(-) T cells especially in smaller AAAs, thus supporting the concept of a T cell-mediated pathophysiology of AAAs, especially during the early development of AAAs. Further research should now assess the possible benefit of anti-inflammatory therapeutic approaches in AAA patients, especially with small AAAs.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies - immunology
- Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - immunology Aortic Aneurysm, Abdominal - therapy
- Biological Markers - blood
- Histocompatibility Antigens Class I - immunology
- Humans -
- Immunotherapy -
- Inflammation Mediators - blood
- Find related publications in this database (Keywords)
- abdominal aortic aneurysms
- inflammation
- lymphocytes
- interferon-gamma
- costimulatory molecule