Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hinghofer-Szalkay, HG; Noskov, VB; Rössler, A; Grigoriev, AI; Kvetnansky, R; Polyakow, VV.
Endocrine status and LBNP-induced hormone changes during a 438-day spaceflight: a case study.
Aviat Space Environ Med. 1999; 70(1):1-5
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Co-Autor*innen der Med Uni Graz
- Rössler Andreas
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- Abstract:
- We investigated basal levels and lower body negative pressure (LBNP)-induced changes of volume regulating (PRA, aldosterone, AVP, ANP99-126) and other stress-sensitive hormones (catecholamines, cortisol, ACTH) in venous plasma from one cosmonaut before (-45 d), during (3, 170, 287, 430 d) and after (+4, +90 d) a record-breaking long-term (438 d) spaceflight. Blood was taken at the beginning and immediately after ending LBNP (-15/-30/-35 mm Hg for 15/15/10 min, respectively) preflight supine, inflight, and postflight supine. PRA, aldosterone, and vasopressin levels stayed within normal boundaries during the entire flight and after landing. Catecholamines exceeded reference limits (epinephrine > 140 pg x ml(-1), norepinephrine >1000 pg x ml(-1) 5 and 9 mo inflight, and 4 d postflight. ANP and cGMP were lower inflight (p<0.04) than pre- or postflight. Cortisol and ACTH were not consistently altered. LBNP-induced hormonal changes were not different (p>0.05) in microgravity and 1-G. Based on data from one cosmonaut, we conclude that long-term spaceflight up to 430 d duration appeared to lower plasma ANP and cGMP during flight and occasionally elevate catecholamine levels, without significantly altering LBNP-induced relative hormone changes as compared with those observed on the ground.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological - physiology
- Adrenocorticotropic Hormone - blood
- Aldosterone - blood
- Atrial Natriuretic Factor - blood
- Catecholamines - blood
- Cyclic GMP - blood
- Endocrine System - physiology
- Homeostasis - physiology
- Hormones - blood
- Humans - blood
- Hydrocortisone - blood
- Lower Body Negative Pressure - adverse effects
- Male - adverse effects
- Middle Aged - adverse effects
- Renin - blood
- Space Flight - blood
- Stress - blood
- Supine Position - blood
- Time Factors - blood
- Vasopressins - blood
- Find related publications in this database (Keywords)
- Long-Duration Spaceflight
- Endocrine Blood Volume Regulation
- Cardiovascular Stress
- Atrial Natriuretic
- Peptide
- Venin
- Aldosteron
- Vasopressin
- Catecholamines