Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wachter, R; Schmidt-Schweda, S; Westermann, D; Post, H; Edelmann, F; Kasner, M; Lüers, C; Steendijk, P; Hasenfuß, G; Tschöpe, C; Pieske, B.
Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure.
Eur Heart J. 2009; 30(24):3027-3036
Doi: 10.1093/eurheartj/ehp341
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
- Co-Autor*innen der Med Uni Graz
- Post Heiner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing heart rates, and this contributes to impaired frequency-dependent augmentation of cardiac output. In 17 patients with HFNEF (median age 69 years, 13 female) and seven age-matched control patients, systolic and diastolic function was analysed by pressure-volume loops at baseline heart rate and during atrial pacing to 100 and 120 min(-1). At baseline, relaxation was prolonged and end-diastolic left ventricular stiffness was higher in HFNEF, whereas all parameters of systolic function were not different from control patients. This resulted in smaller end-diastolic volumes, higher end-diastolic pressure, and a lower stroke volume and cardiac index in HFNEF vs. control patients. During pacing, frequency-dependent upregulation of contractility indices (+dP/dt(max) and Ees) occurred similarly in HFNEF and control patients, but frequency-dependent acceleration of relaxation (dP/dt(min)) was blunted in HFNEF. In HFNEF, end-diastolic volume and stroke volume decreased with higher heart rates while both remained unchanged in control patients. In HFNEF, frequency-dependent upregulation of cardiac output is blunted. This results from progressive volume unloading of the left ventricle due to limited relaxation reserve in combination with increased LV passive stiffness, despite preserved force-frequency relation.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Pressure - physiology
- Cardiac Output - physiology
- Cardiac Pacing, Artificial -
- Case-Control Studies -
- Echocardiography -
- Female -
- Heart Failure, Diastolic - physiopathology Heart Failure, Diastolic - therapy
- Heart Rate - physiology
- Humans -
- Male -
- Middle Aged -
- Myocardial Contraction - physiology
- Up-Regulation -
- Find related publications in this database (Keywords)
- Diastolic function
- Heart failure
- Pressure volume loops
- Force-frequency relation