Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Samsonov, MY; Nassonov, EL; Tilz, GP; Geht, BM; Demel, U; Gurkina, GT; Shtutman, VZ; Guseva, AG; Wachter, H; Fuchs, D.
Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis.
Br J Rheumatol. 1997; 36(6):656-660
Doi: 10.1093/rheumatology/36.6.656
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- Co-Autor*innen der Med Uni Graz
- Demel Ulrike
- Tilz Gernot
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- Abstract:
- We determined serum concentrations of neopterin, soluble tumour necrosis factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor (sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis (DM), including 15 patients with primary PM, 13 patients with primary DM, and 16 patients with myositis and systemic sclerosis in overlap. Concentrations of neopterin, sTNF-R and sIL-2R were measured using commercially available immunoassays. Serum neopterin was increased in 35 of 44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%) patients, respectively. There were significant correlations between serum neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P < 0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with clinical (neuromuscular and activities of daily living scores) and laboratory (creatine kinase levels) manifestations of myositis. Increased serum levels of neopterin were associated with non-muscular manifestations of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory marker for ongoing immune activation and global disease activity in PM/DM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Biological Markers -
- Biopterin - analogs and derivatives
- Dermatomyositis - blood
- Female - blood
- Humans - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Polymyositis - blood
- Receptors, Interleukin-2 - blood
- Receptors, Tumor Necrosis Factor - blood
- Solubility - blood
- Find related publications in this database (Keywords)
- Polymyositis
- Dermatomyositis
- Neopterin