Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muehlbacher, M; Nickel, MK; Nickel, C; Kettler, C; Lahmann, C; Gil, FP; Leiberich, PK; Rother, N; Bachler, E; Fartacek, R; Kaplan, P; Tritt, K; Mitterlehner, F; Anvar, J; Rother, WK; Loew, TH; Egger, C.
Mirtazapine treatment of social phobia in women: a randomized, double-blind, placebo-controlled study.
J Clin Psychopharmacol. 2005; 25(6):580-583
Doi: 10.1097/01.jcp.0000186871.04984.8d
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Nickel-Palczynski Marius
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- Abstract:
- Social phobia is an anxiety disorder characterized by extreme fear and phobic avoidance of social and performance situations and by a relatively poor health-related quality of life. The goal of this study was to compare the efficacy of mirtazapine versus placebo in the treatment of patients with social phobia. In 2004, we conducted a randomized, double-blind, placebo-controlled study of mirtazapine in 66 female subjects from the general population meeting the criteria for social phobia. The subjects were randomly assigned in a 1:1 manner to mirtazapine (n = 33) or placebo (n = 33). The treatment lasted 10 weeks. Seven patients dropped out. Primary outcome measures were self-reported changes on the Social Phobia Inventory, Liebowitz Social Anxiety Scale, and Health Survey (SF-36). In comparison with the placebo group and according to the intent-to-treat principle, significant differences on the Social Phobia Inventory and Liebowitz Social Anxiety Scale scales (all P < 0.001), as well as on most (5 from 8) scales of SF-36 (all P < 0.001), were observed in the mirtazapine-treated subjects. All patients tolerated mirtazapine relatively well. Mirtazapine appears to be an effective agent in the treatment of social phobia in women and in the improvement of their health-related quality of life.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Double-Blind Method -
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- Health Status -
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- Mianserin - analogs and derivatives Mianserin - therapeutic use
- Phobic Disorders - drug therapy
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