Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nickel, C; Tritt, K; Muehlbacher, M; Gil, FP; Mitterlehner, FO; Kaplan, P; Lahmann, C; Leiberich, PK; Krawczyk, J; Kettler, C; Rother, WK; Loew, TH; Nickel, MK.
Topiramate treatment in bulimia nervosa patients: a randomized, double-blind, placebo-controlled trial.
Int J Eat Disord. 2005; 38(4):295-300
Doi: 10.1002/eat.20202
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Nickel-Palczynski Marius
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- Abstract:
- OBJECTIVE: The aim of the current study was to test the influence of topiramate on behavior, body weight, and health-related quality of life (HRQOL) in bulimic patients. METHOD: Thirty patients with bulimia nervosa were treated with topiramate in a 10-week randomized, double-blind, placebo-controlled study. The subjects were randomly assigned to receive topiramate (topiramate group [TG]; n = 30) or a placebo (control group [CG]; n = 30). Primary outcome measures were changes in the frequency of binging/purging, in body weight, and on the SF-36 Health Survey (SF-36) scales. RESULTS: In comparison to the CG group (according to the intent-to-treat principle), significant changes in the frequency of binging/purging (a > 50% reduction: TG, n = 11 [36.7%]; CG, n = 1 [3.3%]; p < .001), body weight (difference in weight loss between the two groups: 3.8 kg, 95% confidence interval [CI] = -5.4 to -2.1; p < .001), and SF-36 (all ps < .001) could be seen. All patients tolerated topiramate well. CONCLUSION: Topiramate appears to safe and effective in influencing the frequency of binging/purging, body weight, and HRQOL in bulimic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anticonvulsants - therapeutic use
- Attitude to Health -
- Bulimia - drug therapy
- Comorbidity -
- Double-Blind Method -
- Female -
- Fructose - analogs and derivatives Fructose - therapeutic use
- Health Behavior -
- Humans -
- Personality Assessment - statistics and numerical data
- Psychometrics -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- bulimia nervosa
- topiramate
- frequency of binging/purging
- body weight
- health-related quality of life