Medizinische Universität Graz - Research portal
Selected Publication:
Rotheneder, M; Kostner, GM.
Effects of low- and high-density lipoproteins on the proliferation of human breast cancer cells in vitro: differences between hormone-dependent and hormone-independent cell lines.
INT J CANCER. 1989; 43: 875-879.
Doi: 10.1002/ijc.2910430523
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Dieber-Rotheneder Martina
- Co-authors Med Uni Graz
- Kostner Gerhard
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- Abstract:
- The influence of low- and high-density lipoproteins on the proliferation of human breast cancer cells in culture was studied. We compared total cell number after incubation for 48 hr in culture medium containing or lacking plasma lipoproteins. Marked differences were found between hormone-dependent (MCF-7, T-47-D, ZR-75) and hormone-independent (MDA-MB-231, HBL-100) mammary tumor cell lines. The cells also reacted differently on the different lipoproteins offered in the medium. Human low-density lipoproteins (LDL) exhibited a marked stimulation of the growth of hormone-independent cell lines but no or only toxic effects upon the hormone-sensitive lines. Human high-density lipoproteins (HDL) stimulated the proliferation of all cell lines in a dose-dependent manner but hormone-independent cells showed a higher response. These findings point towards different utilizations of nutrients in hormone-dependent and hormone-independent cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - pathology
- Cell Division - pathology
- Cell Line - pathology
- Female - pathology
- Humans - pathology
- Lipoproteins, HDL - blood
- Lipoproteins, LDL - blood
- Receptors, Estrogen - analysis
- Tumor Cells, Cultured - cytology