Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P; Barthó, L; Matusák, O; Bauer, V.
Calcitonin gene-related peptide action on intestinal circular muscle.
AMER J PHYSIOL 1989 256: G546-G552.
Doi: 10.1152/ajpgi.1989.256.3.G546
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Isolated segments of the guinea pig small intestine were used to examine the effect of calcitonin gene-related peptide (CGRP) on the motor activity of the circular muscle. CGRP (0.3-30 nM) initiated phasic contractions of the circular muscle due to stimulation of cholinergic neurons. Peristalsis, however, was inhibited by CGRP. A further analysis of this effect showed that CGRP had no inhibitory influence on the main, cholinergic, pathway of the ascending enteric reflex (AER) contraction, whereas the hexamethonium- and atropine-resistant pathways of the AER were blocked. The inhibition of the atropine-resistant AER resulted from an action of CGRP on nerves and, since it was antagonized by apamin, might be explained by a CGRP-induced activation of enteric inhibitory neurons. The direct relaxant action of CGRP on the longitudinal muscle was not affected by apamin. These findings indicate a heterogeneity and topical selectivity in the motor actions of CGRP on the gut and suggest that this peptide, when released from nerve endings within the intestine, plays a specific role in the regulation of intestinal motility.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apamin - pharmacology
- Atropine - pharmacology
- Calcitonin - pharmacology
- Calcitonin Gene-Related Peptide - pharmacology
- Carbachol - pharmacology
- Female - pharmacology
- Gastrointestinal Motility - drug effects
- Guinea Pigs - drug effects
- Hexamethonium - drug effects
- Hexamethonium Compounds - pharmacology
- Ileum - drug effects
- Jejunum - drug effects
- Kinetics - drug effects
- Male - drug effects
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Neuropeptides - pharmacology
- Peristalsis - drug effects
- Reflex - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Tetrodotoxin - pharmacology