Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pristauz, G; Bader, AA; Regitnig, P; Haas, J; Winter, R; Tamussino, K.
How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?
Gynecol Oncol. 2009; 115(1): 12-17.
Doi: 10.1016/j.ygyno.2009.07.007
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pristauz-Telsnigg Gunda
- Co-Autor*innen der Med Uni Graz
- Bader Arnim
- Haas Josef
- Regitnig Peter
- Winter Raimund
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative frozen section examination might allow omitting para-aortic dissection. We analyzed the diagnostic accuracy of frozen section examination of PLN in patients with endometrial cancer. METHODS: We reviewed 131 patients with endometrial cancer who underwent surgery including systematic pelvic lymphadenectomy (n=101) or pelvic and para-aortic lymphadenectomy (n=27). Intraoperative frozen section examination of PLN was performed in 72 (55%) patients. Results of frozen section examination were compared with those of final histopathology and the diagnostic accuracy of frozen section examination of PLN was calculated. One pathologist measured the diameters of PLN metastases retrospectively. RESULTS: A total of 1063 and 2666 PLN were analyzed by frozen section examination and by final histopathology, respectively. PLN metastases were found in 7 cases (10%) at frozen section examination, and in 17 cases (24%) at final histopathology (false negative rate, 59%). No false positive cases were noted. The mean diameter of all PLN metastases at final histopathology was 4.3 mm, as compared to 9.0 mm for the metastases detected at frozen section analyses. The mean diameter of PLN metastases missed at frozen section examination was 2.0 mm. CONCLUSION: In this review at a single institution, intraoperative frozen section histology missed nearly two of three endometrial cancer patients with positive nodes. These results do not support tailoring the extent of lymphadenectomy according to the results of frozen section examination.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - pathology Carcinoma, Endometrioid - surgery
- Endometrial Neoplasms - diagnosis Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery
- Female -
- Frozen Sections - methods Frozen Sections - standards
- Humans -
- Lymph Node Excision -
- Lymph Nodes - pathology Lymph Nodes - surgery
- Lymphatic Metastasis -
- Middle Aged -
- Neoplasm Staging -
- Find related publications in this database (Keywords)
- Endometrial cancer
- Frozen section
- Pelvic and para-aortic lymphadenectomy