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Selected Publication:
Malle, E; Gries, A; Kostner, GM; Pfeiffer, K; Nimpf, J; Hermetter, A.
Is there any correlation between platelet aggregation, plasma lipoproteins, apoproteins and membrane fluidity of human blood platelets?
Thromb Res. 1989; 53(2):181-190
Doi: 10.1016/0049-3848(89)90378-2
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- Leading authors Med Uni Graz
- Malle Ernst
- Co-authors Med Uni Graz
- Gries Anna
- Kostner Gerhard
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- Abstract:
- Fluorescence anisotropy (which is inversely related to membrane fluidity) of gel filtered platelets of 18 normolipemic subjects (20-26 years) was measured after incubation with three different fluorescent probes (DPH, TMA-DPH, and 6-As). These values were correlated to both platelet aggregation parameters after stimulation with ADP (4 microM), epinephrine (10 microM) or collagen (2 micrograms/ml PRP) and to plasma lipids, lipoproteins and apoproteins. Fluorescence anisotropy values after DPH-labeling of platelets were only negatively correlated to TG (p less than 0.05). No correlation was found between fluorescence anisotropy values of DPH, TMA-DPH and 6-As to LDL-C, Lp(a), HDL-C and HDL3-C (p less than 0.01). However, fluorescence anisotropy values of DPH and TMA-DPH were negatively correlated to apoproteins A2 and B (p less than 0.05). No correlations were found between fluorescence anisotropy after DPH labeling and different aggregation parameters. TMA-DPH and 6-As fluorescence anisotropy values are correlated to epinephrine induced stimulation (p less than 0.01).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apoproteins - blood
- Fluorescence Polarization - blood
- Humans - blood
- Lipoproteins - blood
- Membrane Fluidity - blood
- Platelet Aggregation - blood