Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Matzhold, EM; Trummer, O; Grünbacher, G; Zulus, B; Boehm, BO; März, W; Renner, W.
Association of polymorphisms in the chemokine receptor CX3CR1 gene with coronary artery disease.
Cytokine. 2009; 47(3):224-227
Doi: 10.1016/j.cyto.2009.06.010
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Matzhold Eva-Maria
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Grünbacher Gerda
- März Winfried
- Trummer Olivia
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Two chemokine receptor CX3CR1 gene variants, V249I and T280M, have been implicated in coronary artery diseases (CAD). Currently no consistent effect has been revealed and their role in cardiovascular disease is still conflicting. In the present study the association of CX3CR1 genotypes with CAD and myocardial infarction (MI) was investigated in the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort, including 3316 individuals in whom cardiovascular disease angiographically has been defined or ruled out. Similarly to previous studies, the alleles I249 and M280 were in strong linkage disequilibrium and formed an I(249)M(280) haplotype. However, there was no relationship between CX3CR1 genotypes or corresponding haplotypes and the prevalence of CAD or MI. Adjusted for classical risk factors (age, sex, hypertension, dyslipidemia, diabetes mellitus and smoking), the odds ratio (OR) of V249I for CAD was 0.95 (95% confidence interval (CI)=0.78-1.15, p=0.61). The OR of T280M for CAD was 0.83 (95% CI=0.66-1.04, p=0.11). Furthermore, CX3CR1 variants were not associated with C-reactive protein levels, age at onset of CAD, severity of CAD and MI. In conclusion, present data of LURIC do not support the hypothesis that common variants of the CX3CR1 gene are associated with the presence of CAD or MI.
- Find related publications in this database (using NLM MeSH Indexing)
- Alleles -
- CX3C Chemokine Receptor 1 -
- Coronary Artery Disease - genetics
- Cross-Sectional Studies -
- Female -
- Genetic Predisposition to Disease -
- Humans -
- Male -
- Middle Aged -
- Myocardial Infarction - genetics
- Polymorphism, Single Nucleotide -
- Receptors, Chemokine - genetics
- Find related publications in this database (Keywords)
- Coronary artery disease
- Myocardial infarction
- Genetics