Medizinische Universität Graz - Research portal
Selected Publication:
Ebner, F; Ranner, G; Slavc, I; Urban, C; Kleinert, R; Radner, H; Einspieler, R; Justich, E.
MR findings in methotrexate-induced CNS abnormalities.
AJR Am J Roentgenol. 1989; 153(6):1283-1288
Doi: 10.2214/ajr.153.6.1283
(- Case Report)
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- Leading authors Med Uni Graz
- Ebner Franz
- Co-authors Med Uni Graz
- Urban Ernst-Christian
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- Abstract:
- MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Brain - pathology
- Brain Diseases - chemically induced
- Child - chemically induced
- Female - chemically induced
- Humans - chemically induced
- Magnetic Resonance Imaging - chemically induced
- Male - chemically induced
- Methotrexate - adverse effects
- Osteosarcoma - drug therapy