Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pilz, S; Tomaschitz, A; Ritz, E; Pieber, TR.
Vitamin D status and arterial hypertension: a systematic review.
Nat Rev Cardiol. 2009; 6(10): 621-630.
Doi: 10.1038/nrcardio.2009.135
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- Leading authors Med Uni Graz
- Pilz Stefan
- Co-authors Med Uni Graz
- Pieber Thomas
- Tomaschitz Andreas
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- Abstract:
- Vitamin D deficiency is common and is primarily caused by a lack of ultraviolet-B (UVB) radiation from reduced sun exposure, and the consequent limiting of vitamin D production in the skin. The vitamin D endocrine system regulates about 3% of the human genome. Observational data support the concept that vitamin D is involved in the pathogenesis of cardiovascular diseases and arterial hypertension. The antihypertensive properties of vitamin D include renoprotective effects, suppression of the renin-angiotensin-aldosterone system, direct effects on vascular cells, and effects on calcium metabolism, including prevention of secondary hyperparathyroidism. The results of clinical studies largely, but not consistently, favor the hypothesis that vitamin D sufficiency promotes lowering of arterial blood pressure. Randomized, placebo-controlled trials are greatly needed to clarify and definitively prove the effect of vitamin D on blood pressure. In general, the antihypertensive effects of vitamin D seem to be particularly prominent in vitamin-D-deficient patients with elevated blood pressure. Thus, in view of the relatively safe and inexpensive way in which vitamin D can be supplemented, we believe that vitamin D supplementation should be prescribed to patients with hypertension and 25-hydroxyvitamin D levels below target values.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use
- Blood Pressure - drug effects
- Calcium - metabolism
- Dietary Supplements - adverse effects
- Evidence-Based Medicine -
- Humans -
- Hypertension - blood Hypertension - drug therapy Hypertension - etiology Hypertension - physiopathology
- Renin-Angiotensin System - drug effects
- Treatment Outcome -
- Vitamin D - adverse effects Vitamin D - analogs and derivatives Vitamin D - blood Vitamin D - therapeutic use
- Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy Vitamin D Deficiency - physiopathology