Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yazdani-Biuki, B; Krippl, P; Brickmann, K; Fuerst, F; Langsenlehner, U; Paulweber, B; Pilger, E; Wascher, TC; Brezinschek, HP; Renner, W.
The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease.
Angiology. 2010; 61(2):211-215
Doi: 10.1177/0003319709337305
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Yazdani-Biuki Babak
- Co-Autor*innen der Med Uni Graz
- Brezinsek Hans-Peter
- Brickmann Kerstin
- Krippl Peter
- Langsenlehner Uwe
- Moazedi-Fürst Florentine
- Pilger Ernst
- Wascher Thomas
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- Abstract:
- Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12 -4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F124C>T polymorphism is not associated with PAD.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Case-Control Studies -
- Factor XII - genetics
- Female -
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Partial Thromboplastin Time -
- Peripheral Vascular Diseases - genetics
- Polymorphism, Genetic -
- Promoter Regions, Genetic - genetics
- Risk Factors -
- Smoking - epidemiology
- Find related publications in this database (Keywords)
- peripheral arterial disease
- coagulation factor XII
- genetics
- polymorphism