Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Burdach, S; Thiel, U; Schöniger, M; Haase, R; Wawer, A; Nathrath, M; Kabisch, H; Urban, C; Laws, HJ; Dirksen, U; Steinborn, M; Dunst, J; Jürgens, H.
Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases.
Bone Marrow Transplant. 2010; 45(3): 483-489.
Doi: 10.1038/bmt.2009.184
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Urban Ernst-Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We examined the role of total body magnetic resonance imaging (TB-MRI)-governed involved compartment irradiation (ICI) and high-dose chemotherapy (HDC), followed by stem cell rescue (SCR) in patients with high-risk Ewing tumors (ETs) with multiple primary bone metastases (high-risk ET-MBM). Eleven patients with high-risk ET-MBM receiving initial assessment of involved bones by TB-MRI were registered from 1995 to 2000 (group A). In all, 6 patients out of 11 had additional lung disease at initial diagnosis; all had multifocal bone disease with more than three bones involved. After systemic induction with etoposide, vincristine, adriamycin (doxorubicin), ifosfamide, and actinomycin D (EVAIA) or VAIA chemotherapy, ICI of all sites positive by TB-MRI was administered, followed by HDC and SCR. A second group matched for observation period and consisting of 26 patients with more than three involved bones at diagnosis was treated with the European Intergroup Cooperative Ewing Sarcoma Study-92 (EICESS-92) protocol (group B). These patients did not receive TB-MRI and consequently did not receive TB-MRI-governed ICI, or HDC and SCR. Survival in group A vs group B was 45 vs 8% at 5 years and 27 vs 8% at 10 years after diagnosis (log rank and Breslow: P<0.005). We conclude that TB-MRI-governed ICI followed by HDC and SCR in ET-MBM is feasible and warrants further evaluation in prospective studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antineoplastic Combined Chemotherapy Protocols - administration and dosage
- Bone Neoplasms - drug therapy
- Child -
- Clinical Protocols -
- Combined Modality Therapy -
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Kaplan-Meier Estimate -
- Magnetic Resonance Imaging -
- Male -
- Sarcoma, Ewing - drug therapy
- Whole-Body Irradiation - methods
- Young Adult -
- Find related publications in this database (Keywords)
- high-risk Ewing tumor
- high-dose chemotherapy
- involved compartment irradiation
- total body MRI