Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rothenhäusler, HB; Scherr, M; Putz-Bankuti, C; Kapper, A; Stepan, A; Baranyi, A; Haas-Krammer, A; Haas, B; Stauber, R.
The relationship between emotional distress, cognitive performance and health - related quality of life in patients with hepatitis C prior to antiviral treatment.
Fortschr Neurol Psychiatr. 2009; 77(8): 457-463.
Doi: 10.1055/s-0028-1109574
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- Führende Autor*innen der Med Uni Graz
- Rothenhäusler Hans-Bernd
- Co-Autor*innen der Med Uni Graz
- Baranyi Andreas
- Krammer Alexandra
- Putz-Bankuti Csilla
- Scherr Martin
- Stauber Rudolf
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- Abstract:
- Recent epidemiologic studies suggest that more than 175 million individuals are infected with hepatitis C virus (HCV) worldwide. In the past few years, outcome studies in chronic HCV patients are no longer focusing solely on traditional end points such as mortality rates but on psychosocial well-being such as health-related quality of life (HRQoL), emotional states, and neuropsychological functioning. The purpose of our exploratory study was to assess cross sectionally the frequency of depression, posttraumatic stress symptoms, cognitive deficits, and impairments in HRQoL in chronic HCV patients prior to antiviral treatment, and to investigate how cognitive impairments and emotional distress were related to quality of life. We recruited 34 chronic HCV patients who had presented for initial assessment of the need for antiviral therapy. Psychometric observer-rating and self-rating scales were administered to evaluate posttraumatic stress symptoms (PTSS-10), depressive symptoms (BDI), HRQoL (SF-36 Health Status Questionnaire), and cognitive functioning (SKT). 32.4 % (n = 11) of the sample suffered from clinical depression, and 8.8 % (n = 3) had a posttraumatic stress syndrome. 8.8 % (n = 3) of the sample showed cognitive impairments. Significant impairments in HRQoL were found in the health-related domains vitality, role-emotional, and role-physical. The severity of emotional distress as measured on the BDI and PTSS-10 was associated with decrements in HRQoL. However, lower cognitive function scores on the SKT were not associated with lower HRQoL SF-36 values. Chronic HCV patients seem to face a major risk of depression, posttraumatic stress symptoms, and cognitive dysfunction, and the presence of emotional distress is associated with impairments in quality of life. We therefore underscore the need for early and comprehensive bio-psycho-social diagnosis and therapy of chronic HCV patients in order to treat emotional distress and enhance patients; quality of life at an early stage before initiating antiviral therapy, as well as to expand the pool of patients eligible to receive antiviral therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Affective Symptoms - epidemiology Affective Symptoms - psychology
- Aged -
- Antiviral Agents - therapeutic use
- Cognition - physiology
- Depression - epidemiology Depression - psychology
- Female -
- Health Status -
- Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - psychology
- Humans -
- Male -
- Middle Aged -
- Neuropsychological Tests -
- Psychomotor Performance -
- Quality of Life -
- Socioeconomic Factors -
- Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - psychology
- Find related publications in this database (Keywords)
- Hepatitis C
- psychiatric comorbidities
- health-related quality of life
- consultation-liaison psychiatry