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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pilz, S; Tomaschitz, A; Obermayer-Pietsch, B; Dobnig, H; Pieber, TR.
Epidemiology of vitamin D insufficiency and cancer mortality.
Anticancer Res. 2009; 29(9): 3699-3704.
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- Leading authors Med Uni Graz
- Pilz Stefan
- Co-authors Med Uni Graz
- Dobnig Harald
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Tomaschitz Andreas
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- Abstract:
- There is growing evidence that vitamin D exerts anticarcinogenic effects. Ultraviolet-B (UV-B) radiation, which is required for vitamin D production in the skin, was found to be inversely associated with cancer incidence and mortality. Recent studies have largely but not consistently shown that low 25-hydroxyvitamin D (25(OH)D) levels, which are considered to be the best indicator of vitamin D status, are a significant risk factor for cancer mortality. Circulating 25(OH)D levels were also associated with improved survival in colorectal and lung cancer patients and vitamin D insufficiency was observed in various other diseases such as autoimmune, infectious, musculoskeletal, neurological and cardiovascular diseases. In conclusion, we still need further studies to evaluate the association of vitamin D insufficiency and cancer incidence and mortality, but the multiple health benefits of vitamin D and the easy, safe and inexpensive way by which vitamin D can be supplemented should already guide current public health strategies to achieve 25(OH)D levels of at least 75 nmol/l (30 ng/ml) in the general population.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans -
- Incidence -
- Neoplasms - epidemiology Neoplasms - mortality
- Ultraviolet Rays -
- Vitamin D - analogs and derivatives Vitamin D - blood
- Vitamin D Deficiency - epidemiology
- Find related publications in this database (Keywords)
- 25-Hydroxyvitamin D
- 1,25-dihydroxyvitamin D
- survival
- vitamin D supplementation
- review