Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Klaushofer, K; Hoffmann, O; Hörandner, H; Karasegh, S; Fratzl-Zelman, N; Leis, HJ; Gleispach, H; Koller, K; Peterlik, M.
Effect of auranofin on resorption, prostaglandin synthesis and ultrastructure of bone cells in cultured mouse calvaria.
J Rheumatol. 1989; 16(6):749-756
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- Co-Autor*innen der Med Uni Graz
- Leis Hans-Joerg
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- Abstract:
- Auranofin (AF) in concentrations between 3 x 10(-7) and 3 x 10(-6) mol/l stimulated bone resorption in cultured neonatal mouse calvariae significantly with 1 x 10(-6) mol/l being most potent. Complete inhibition by 5 x 10(-7) mol/l indomethacin and increased medium concentrations of prostaglandin (PG) E2 and 6-keto-PGF1 alpha after 72 h indicate a PG mediated mechanism. Morphology revealed active osteoclasts. Cytotoxic effects were observed with 3 x 10(-6) and 1 x 10(-5) mol/l AF with osteocytes and osteoblasts being considerably more sensitive than osteoclasts. The latter concentrations inhibited bone resorption stimulated by parathyroid hormone (PTH) 1,25-dihydroxyvitamin D3, PGE2, thrombin and interleukin 1. The stimulatory effect of AF on PG production and subsequent bone resorption could limit its therapeutic usefulness.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Auranofin - pharmacology
- Bone Resorption - drug effects
- Bone and Bones - drug effects
- Cells, Cultured - drug effects
- Mice - drug effects
- Prostaglandins - biosynthesis
- Skull - biosynthesis