Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wruck, CJ; Huppertz, B; Bose, P; Brandenburg, LO; Pufe, T; Kadyrov, M.
Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia.
HISTOPATHOLOGY. 2009; 55(1): 102-106.
Doi: 10.1111/j.1365-2559.2009.03339.x
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Aims: Increasing evidence suggests that oxidative stress may play a key role in the aetiology of preeclampsia (PE). The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2). Methods and results: Expression of Nrf2 in third-trimester placental tissue was compared in preeclamptic and normal gestation-matched controls. PE was associated with increased Nrf2 activity within cytotrophoblastic nuclei. Nrf2 expression was restricted to proliferative and early post-proliferative cytotrophoblast only. Syncytiotrophoblast was immunonegative for Nrf2 in both controls and preeclamptic placentas. Conclusions: Nrf2 is exclusively active within cytotrophoblast, strongly suggesting that these cells are the origin of Nrf2-dependent gene products. Syncytiotrophoblast is transcriptionally inactive; therefore in times of oxidative stress essential cytoprotective enzymes must be derived from the cytotrophoblast. Excessive cytotrophoblastic turnover causes disproportionate release of toxic placental factors, manifesting as PE and endangering maternal health. Increased cytotrophoblastic proliferation/fusion could thus be interpreted as a fetal defence mechanism, initiated in response to the requirements of vulnerable syncytiotrophoblast. We therefore propose a direct relationship between fetal defence against oxidative stress and consequent placental toxicity as part of the aetiology of this complex maternal disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Case-Control Studies -
- Cell Proliferation -
- Defense Mechanisms -
- Female -
- Fetus - metabolism
- Humans -
- NF-E2-Related Factor 2 - metabolism
- Oxidative Stress - physiology
- Placenta - metabolism
- Pre-Eclampsia - etiology
- Pregnancy -
- Pregnancy Trimester, Third - physiology
- Trophoblasts - cytology
- Find related publications in this database (Keywords)
- cytotrophoblastic proliferation
- Nrf2
- nuclear factor erythroid-2-related factor 2
- oxidative stress
- preeclampsia