Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Benesch, M; Urban, C; Platzbecker, U; Passweg, J.
Stem cell transplantation for patients with Evans syndrome
EXPERT REV CLIN IMMUNOL. 2009; 5(3): 341-348.
Doi: 10.1586/eci.09.9
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Urban Ernst-Christian
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- Abstract:
- Evans syndrome (ES) is a chronic hematological disorder characterized by autoimmune hemolytic anemia and immune-mediated thrombocytopenia that often requires profound and long-term immunosuppression. Only a few small case series or single case studies of autologous and allogeneic hematopoietic stem cell transplantation (HSCT) in patients with ES have been reported in the literature, with long-term remissions being observed after both autologous and allogeneic HSCT. Patients with ES suffering from refractory disease, multiple relapses and serious disease-related complications should be offered allogeneic HSCT, which is the only treatment with curative potential. Autologous HSCT might be preferable in patients with serious preexisting comorbidities lacking an HLA-identical donor. Owing to the rarity of this disease and the small number of patients receiving HSCT for ES, prospective controlled studies on this approach are not available. A prospective registration of patients transplanted for ES would allow the development of optimal transplant strategies.
- Find related publications in this database (Keywords)
- allogeneic hematopoietic stem cell transplantation
- autologous hematopoietic stem
- cell transplantation
- Evans syndrome