Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gebeshuber, CA; Zatloukal, K; Martinez, J.
miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis.
EMBO Rep. 2009; 10(4): 400-405.
Doi: 10.1038/embor.2009.9
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- Co-Autor*innen der Med Uni Graz
- Zatloukal Kurt
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- Abstract:
- Several microRNAs (miRNAs) have recently been described as crucial regulators of epithelial-to-mesenchymal transition (EMT) and metastasis. By comparing the expression profiles of miRNAs, we found upregulation of miR-29a in mesenchymal, metastatic RasXT cells relative to epithelial EpRas cells. Overexpression of miR-29a suppressed the expression of tristetraprolin (TTP), a protein involved in the degradation of messenger RNAs with AU-rich 3'-untranslated regions, and led to EMT and metastasis in cooperation with oncogenic Ras signalling. We also observed enhanced miR-29a and reduced TTP levels in breast cancer patient samples, indicating relevance for human disease. Previously, miR-29 family members were shown to have tumour-suppressive effects in haematopoietic, cholangiocytic and lung tumours. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blotting, Northern -
- Blotting, Western -
- Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology
- Cell Line -
- Cell Line, Tumor -
- Epithelial Cells - metabolism Epithelial Cells - pathology
- Gene Expression Regulation, Neoplastic -
- Humans -
- Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology
- Mesoderm - metabolism Mesoderm - pathology
- Mice -
- Mice, Nude -
- MicroRNAs - genetics MicroRNAs - physiology
- Mutagenesis, Site-Directed -
- Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology
- Oligonucleotide Array Sequence Analysis -
- Polymerase Chain Reaction -
- RNA, Small Interfering -
- Tristetraprolin - metabolism Tristetraprolin - physiology
- Find related publications in this database (Keywords)
- breast cancer
- metastasis
- miR-29a
- miRNA
- tristetraprolin