Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Idris, T; Winter, R; Lang, U; Petru, E.
Topotecan-induced long-term remission of an advanced endometrial cancer after treatment with cisplatinum, an anthracycline and paclitaxel.
ANTICANCER RES. 2009; 29(5): 1761-1762.
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Idris Tina
- Co-Autor*innen der Med Uni Graz
- Lang Uwe
- Petru Edgar
- Winter Raimund
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- Abstract:
- BACKGROUND: The optimal palliative chemotherapy in endometrial cancer is unknown. CASE REPORT: A patient was diagnosed to have primary endometrioid endometrial cancer metastatic to the pelvic, paraaortic and right inguinal lymph nodes (FIGO IVb). After radical surgery, she received 6 adjuvant cycles of cisplatin and epirubicin. Twelve months later, she developed a pelvic recurrence and received second-line paclitaxel chemotherapy. Three months thereafter, computed tomography showed diffuse peritoneal carcinomatosis with lesions up to 2 cm in diameter. She received eighteen weekly cycles of topotecan which led to a complete clinical response confirmed by CT. Forty-three months after the start of third-line chemotherapy with topotecan, the patient is alive with no evidence of disease. CONCLUSION: Long-term survival with NED may be achievable by topotecan in selected patients with an initial diagnosis of extensive endometrial cancer despite repeated relapses and previous exposure to cisplatinum, an anthracycline and a taxane.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Cisplatin - administration and dosage
- Endometrial Neoplasms - drug therapy
- Female -
- Humans -
- Middle Aged -
- Paclitaxel - administration and dosage
- Remission Induction -
- Topotecan - administration and dosage Topotecan - therapeutic use
- Find related publications in this database (Keywords)
- Topotecan
- endometrial cancer
- anthracyclines
- taxanes
- stage IV disease