Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wedemeyer, H; Schuller, E; Schlaphoff, V; Stauber, RE; Wiegand, J; Schiefke, I; Firbas, C; Jilma, B; Thursz, M; Zeuzem, S; Hofmann, WP; Hinrichsen, H; Tauber, E; Manns, MP; Klade, CS.
Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C.
Vaccine. 2009; 27(37): 5142-5151.
Doi: 10.1016/j.vaccine.2009.06.027
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Stauber Rudolf
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- Abstract:
- We examined the effect of the hepatitis C virus (HCV) peptide vaccine IC41 on HCV-specific T-cell responses and virological relapse rates in patients with chronic HCV genotype 1 infection when added to pegylated interferon plus ribavirin standard therapy. 35 patients received 6 vaccinations with IC41 from weeks 28 to 48 of standard antiviral treatment and were followed-up for another 6 months. IC41 vaccination did not prevent HCV-RNA relapse in patients with ongoing interferon standard treatment but HCV-specific T-cell responses were inducible and were associated with lower relapse rates. An increase of HCV-specific T-cell responses occurred in 73% of patients, responses were more frequent and stronger in patients with sustained virologic response than in patients who relapsed. Optimized vaccine responses may enhance sustained virologic response rates obtained with standard treatment of chronic hepatitis C.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- CD4-Positive T-Lymphocytes - immunology
- CD8-Positive T-Lymphocytes - immunology
- Cell Proliferation -
- Cells, Cultured -
- Female -
- Hepatitis C, Chronic - immunology
- Humans -
- Interferons - therapeutic use
- Male -
- Middle Aged -
- Recurrence -
- Ribavirin - therapeutic use
- Treatment Outcome -
- Vaccines, Subunit - immunology
- Viral Hepatitis Vaccines - immunology
- Young Adult -
- Find related publications in this database (Keywords)
- Hepatitis C virus
- IC41
- Sustained virologic response