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Kröll, W; Wisiak, UV; List, WF.
Preoperative subjective anxiety. Double blind study using oxazepam
ANAESTHESIST. 1988; 37(12): 752-757.
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Leading authors Med Uni Graz: Kröll Wolfgang
Co-authors Med Uni Graz: Wisiak Ursula
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Abstract:: Amnesia for unpleasant experiences in the immediate preoperative period, reduction of anxiety, and sedation are the major goals of premedication. The purpose of this randomized double-blind study was to evaluate the anxiolytic effects of the benzodiazepine oxazepam. Following approval by the ethics commission and informed consent, 60 ASA class I and II female patients undergoing surgical treatment of radiologically evaluated breast lesions were studied prospectively using the Mannheim protocol for subjective feeling (MESB) and the State-Trait Anxiety Inventory (STAI) to evaluate intensity levels of preoperative anxiety. During a preoperative visit patients were informed about the management of the study: they were asked to report their subjective feelings preoperatively and immediately before induction. Either oxazepam 30 mg or placebo was administered orally in a double-blind manner 90 min before induction. Preoperative anxiety levels were high in both groups. Following administration of the drug, anxiety-intensity decreased significantly on the MESB and STAI. Oxazepam is a useful oral premedicant for providing effective anxiolysis in the immediate perioperative period compared to placebo. The Mannheim protocol for subjective feeling seems to be a better scoring system for evaluating perioperative anxiety as compared to the STAI. It consists of criteria with which the patients can identify themselves during the perioperative phase.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Anxiety - drug therapy; Breast - surgery; Clinical Trials - surgery; Double-Blind Method - surgery; Female - surgery; Humans - surgery; Oxazepam - therapeutic use; Personality Inventory - therapeutic use; Preanesthetic Medication - therapeutic use