Medizinische Universität Graz - Research portal
Selected Publication:
Gombotz, H; Metzler, H; Winkler, G; Rehak, P.
Intraoperative heart rate reduction--alinidine versus metoprolol.
Acta Anaesthesiol Scand. 1988; 32(8):686-690
Doi: 10.1111/j.1399-6576.1988.tb02809.x
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- Co-authors Med Uni Graz
- Metzler Helfried
- Rehak Peter
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- Abstract:
- In a double-blind randomized protocol the effectiveness of the specific bradycardic agent alinidine (0.6 mg.kg-1 i.v.) was compared to that of the betablocker metoprolol (0.035 mg.kg-1 i.v.). Twenty-four coronary artery disease patients undergoing a bypass procedure with an intraoperative heart rate increase of more than 20% were included. Patients with a concomitant intraoperative mean arterial pressure increase of more than 30% or with an intraoperative wedge pressure higher than 15 mmHg (2.0 kPa) were excluded. After application of alinidine and metoprolol, heart rate decreased significantly (P less than 0.01) in the alinidine group from 88 +/- 19 beats per min to 72 +/- 13 and in the metoprolol group from 82 +/- 16 to 72 +/- 12. Baseline values were not obtained. Compared to the hemodynamic changes in the metoprolol group, the alterations of pulmonary capillary wedge pressure (PCWP) (P less than 0.05), stroke volume index (SVI) (P less than 0.05), left ventricular stroke work index (LVSWI) (P less than 0.01) and right ventricular stroke work index (RVSWI) (P less than 0.05) in the alinidine group were statistically significantly different. PCWP remained unchanged after alinidine and increased in the metoprolol group (1.4 +/- 0.4 to 1.6 +/- 0.4 kPa). In the alinidine group LVSWI (43.1 +/- 15 to 49.2 +/- 18 g-m.m-2), RVSWI (5.1 +/- 4 to 6.6 +/- 3 g-m.m-2) and SVI (37.2 +/- 12.2 to 42.5 +/- 12.8 ml.m-2) increased.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anti-Arrhythmia Agents - therapeutic use
- Clinical Trials as Topic - therapeutic use
- Clonidine - analogs and derivatives
- Depression, Chemical - analogs and derivatives
- Double-Blind Method - analogs and derivatives
- Female - analogs and derivatives
- Heart Rate - drug effects
- Humans - drug effects
- Intraoperative Period - drug effects
- Male - drug effects
- Metoprolol - therapeutic use
- Middle Aged - therapeutic use
- Random Allocation - therapeutic use