Medizinische Universität Graz - Research portal
Selected Publication:
Leis, HJ; Gleispach, H; Malle, E; Nitsche, V.
Femtomole analysis of diclofenac in human plasma by gas chromatography/negative ion chemical ionization/mass spectrometry using (18O2)diclofenac as internal standard.
BIOMED ENVIRON MASS SPECTROM. 1988; 17(4): 307-310.
Doi: 10.1002/bms.1200170414
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PubMed
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- Leading authors Med Uni Graz
- Leis Hans-Joerg
- Co-authors Med Uni Graz
- Malle Ernst
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- Abstract:
- A stable isotope dilution gas chromatography/negative ion chemical ionization/mass spectrometry assay for diclofenac in human plasma is described. The preparation of (18O2)diclofenac and its use as an internal standard for quantitative gas chromatography/mass spectrometry is shown. A sample processing and derivatization sequence with product recovery of 84.7% was found. The method presented permits quantitative measurement of diclofenac in human plasma at the lower femtomole level. Plasma levels of diclofenac after administration of diclofenac gel were estimated.
- Find related publications in this database (using NLM MeSH Indexing)
- Diclofenac - blood
- Gas Chromatography-Mass Spectrometry - methods
- Humans - methods
- Isotope Labeling - methods
- Oxygen Isotopes - methods